Harrison's Principles of Internal Medicine. Terms Privacy Security Cookies. Limited scleroderma, also known as CREST syndrome, is one subtype of scleroderma — a condition whose name means "hardened skin. The documents contained in this web site are presented for information purposes only. Unsourced material may be challenged and removed.
Vasculopathy and fibrosis also occur in the gastrointestinal tract, leading to esophageal dysmotility, another prominent feature of CREST syndrome.
Marked Telangiectasias dilated capillaries occur on the skin of the face, the palmar surface of the hands, and the mucous membranes. Multiple studies have evaluated such hypotheses as a primary injury to blood vessel endothelial cells, dysregulation of fibroblasts, viral infection leading to increased susceptibility, various forms of autoimmunity including a graft-vs-host disease from retained maternal fetal lymphocytesand silica exposure. Are these symptoms normal? Second, there has been an association with biliary cirrhosis. Views Read Edit View history.